Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA

Rothman Institute Orthopaedics

Status: Unknown

Conditions: MRSA/ MSSA Colonization of the Nares

Treatments: Drug: 5% Povidone-Iodine USP swabs; Drug: Povidone-Iodine; Drug: Saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02652325

2016JPAR

Details and patient eligibility

About

To determine if routinely available 10% povidone-iodine swabs are more effective than saline and 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP for decolonizing MRSA.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. All potential total hip and total knee arthroplasty candidates
2. All femoroacetabular osteoplasty patients
3. All pelvic acetabular osteotomy patients
4. All core decompression patients

Exclusion criteria

1. Any trauma patients
2. Any tumor patients
3. Any patient with periprosthetic joint infection
4. Any patient with surgical site infection
5. Any patient with known MRSA infection
6. Any patients allergic to povidone-iodine
7. Patients with thyroid disease

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 3 patient groups, including a placebo group

povidone-iodine

Active Comparator group

Treatment:

Drug: Povidone-Iodine

3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP swabs

Active Comparator group

Treatment:

Drug: 5% Povidone-Iodine USP swabs

Saline

Placebo Comparator group

Treatment:

Drug: Saline