Nasopharyngeal Airway Facilitate Transnasal Humidified Rapid Insufflation Ventilatory Exchange

Shanghai Jiao Tong University logo

Shanghai Jiao Tong University

Status

Unknown

Conditions

Hypercapnia
Hypoxia

Treatments

Device: Nasopharyngeal airway

Study type

Interventional

Funder types

Other

Identifiers

NCT03741998
RenJiH[2018]011

Details and patient eligibility

About

For performing transnasal humidified rapid insufflation ventilatory exchange (THRIVE), jaw-thrust maneuver have to maintain to make sure the airway open and the CO2 clearance during apnoea. The objective of present study is to prove that nasopharyngeal airway facilitate THRIVE and no need jaw-thrust maneuver and maintain the similar PO2 and PCO2 during apnoea.

Enrollment

120 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Signed informed consent.
  • Undergoing surgery with general anaesthesia.
  • Adult, >18 years old.
  • American Society of Anesthesiology classification I-II.

Exclusion criteria

  • Coagulation disorders or a tendency of nose bleeding
  • An episode/exacerbation of congestive heart failure (CHF) that requires a change in medication, diet or hospitalization from any cause in the last 6 months
  • Severe aortic stenosis or mitral stenosis;
  • Cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (CABG), valve replacement surgery) in the last 6 months;
  • Acute myocardial infarction in the last 6 months;
  • Acute arrhythmia (including both tachycardia and bradycardia) with hemodynamic instability;
  • Diagnosed COPD or current other acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy);
  • Increased intracranial pressure;
  • ASA >II;
  • Mouth, nose, or throat infection;
  • Fever, defined as core body temperature > 37.5°C;
  • Pregnancy, breastfeeding or positive pregnancy test;
  • Emergency procedure.
  • Patient with known or suspected difficult airway

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

120 participants in 2 patient groups

THRIVE
No Intervention group
Description:
Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) during induction using jaw-thrust maneuver.
THRIVE with nasopharyngeal airway
Active Comparator group
Description:
Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) during induction with nasopharyngeal airway.
Treatment:
Device: Nasopharyngeal airway

Trial contacts and locations

0

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Central trial contact

Diansan Su, Dr.

Data sourced from clinicaltrials.gov

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