Nasopharynx Microbiota Component and in Vitro Cytokines Production in Coronavirus Disease (COVID-19) (8796)

Başakşehir Çam & Sakura City Hospital

Status: Unknown

Conditions: Covid19

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT04708912

8796

Details and patient eligibility

About

The investigators will study nasopharunx microbiota composition, RNA sequences and in vitro cytokines production by peripheral blood cells of COVID-19 patients (both mild-moderate and severe cases) (comparing with convalescent patients and healthy controls).

Full description

The investigators will compare study parameters (basal) between mild-moderate and severe COVID-19 patients and with other study groups (i.e. convalescent and healthy controls). Nasopharunx microbiota dysbiosis, in vitro cytokines production profile, and peripheral blood flocytometric results of the four study groups will be compared.

In vitro cytokines production will be studied and compared in Nill (No antigens) and Mitojen (Cocktail of antigens) pre-prepared test tubes.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ability to give a written consent

Exclusion criteria

• In ability to give a written consent
• Using of medications that affect the results of study parameters
• Presence of malignancy or tuberculosis

Trial design

100 participants in 4 patient groups

1

Description:

Mild-Moderate COVID-19

Treatment:

Other: Observation

2

Description:

Severe COVID-19

Treatment:

Other: Observation

3

Description:

Convalsent (COVID-19)

Treatment:

Other: Observation

4

Description:

Healthy persons