NASPI: N-Acetylcysteine vs. Ascorbic Acid for Prevention of Contrast Induced Nephropathy in Renal Insufficiency Undergoing Coronary Catheterization

Seoul National University

Status and phase

Completed

Phase 4

Conditions

Kidney Failure

Treatments

Drug: ascorbic acid

Drug: N-acetylcystein

Study type

Interventional

Funder types

Other

Identifiers

NCT00356954

H-0509-517-158-2

Details and patient eligibility

About

The contrast induced nephropathy (CIN) has been known to be associated with significant clinical and economic consequences. Many studies were performed to find the pathophysiology and preventive measures for CIN. But the results were somewhat frustrating. Recently, it has been reported that the N-acetylcysteine and ascorbic acid might have preventive effects for CIN by their antioxidant effects.There have been no study to compare these two antioxidant.

Full description

N-acetylcysteine and ascorbic acid may prevent the CIN in the patients with underlying renal insufficiency who is undergoing the coronary angiography. The effect may derive from the antioxidant function of these two antioxidant. We studied to find which of the two antioxidants is more beneficial in prevention of CIN

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Stable Angina pectoris patients
Patients who required the coronary catheterization
Creatinine clearance rates =<60 mL/min using the Cockcroft-Gault formula
Age of 19 or over 19

Exclusion criteria

Pregnancy
Lactation
Having received contrast media within 7 days of study entry
Emergent coronary angiography
Acute renal failure
End-stage renal disease requiring dialysis
History of hypersensitivity reaction to contrast media
Cardiogenic shock
Pulmonary edema
Multiple myeloma
Mechanical ventilation
Parenteral use of diuretics
Recent use of N-acetylcysteine
Recent use of Ascorbic acid
Recent use of statin
Use of metformin or nonsteroidal anti-inflammatory drugs within 48 hours of the procedure.