National Bacterial Meningitis Study

Association Clinique Thérapeutique Infantile du val de Marne

Status: Enrolling

Conditions: Meningococcal Vaccines; Meningitis; Case Fatality Rate; Pneumococcal Conjugate Vaccine; Children, Only; Neonatal Infection; Antibiotic Treatment; H. Influenzae Vaccine

Treatments: Other: observational study

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04664569

Obs meningitis

Details and patient eligibility

About

Bacterial meningitis is a major cause of morbidity and mortality in childhood. Antibiotic treatment recommendations are based on epidemiological and susceptibility data. The epidemiology of bacterialméningitis has changed in recent years, mainly owing to widespread use of different conjugate vaccines. The aim of this prospective national survey is to describe epidemiology of bacteria implicated in bacterial meningitis in children.

Enrollment: 8,230 estimated patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical signs of meningitis, associated with positive cerebrospinal fluid (CSF) culture and/or positive CSF antigen testing (Escherichia coli K1, N. meningitidis serogroups B, A, C, Y and W-135, group B streptococci, Hib, or S. pneumoniae), and/or positive CSF polymerase chain reaction (PCR), and/or positive blood culture with CSF pleocytosis (> 10 cells/µL).
• purpura fulminans

Exclusion criteria

Trial design

8,230 participants in 1 patient group

Cohort of bacterial meningitis in children

Treatment:

Other: observational study