National Longitudinal Cohort of Hematological Diseases (NICHE)

Institute of Hematology & Blood Diseases Hospital, China

Status

Enrolling

Conditions

Hemophilia B

Blood Disease Infection

Leukemia

Hemophilia As

MDS

Multiple Myeloma

Myelomas, Multiple

Myeloma, Multiple

Lymphoma

Hemophilia Bs

Bleeding Disorder

Aplastic Anemia

Myelodysplastic Syndrome

Hemophilia A

Leukemias, Acute Myeloid

Bone Marrow Transplantation

Hemophilia

Acute Myeloid Leukemia

Myeloid Leukemias, Acute

Study type

Observational

Funder types

Other

Identifiers

NCT04645199

NICHE-cohort

Details and patient eligibility

About

Background Hematological diseases are disorders of the blood and hematopoietic organs. The current hematological cohorts are mostly based on single-center or multi-center cases, or cohorts with limited sample size in China. There is a lack of comprehensive and large-scale prospective cohort studies in hematology. The purpose of this study is to analyze the incidence and risk factors of major blood diseases, the treatment methods, prognosis and medical expenses of these patients in China.

Method The study will include patients diagnosed with acute myeloid leukemia, multiple myeloma, hemophilia, aplastic anemia, leukemia, myelodysplastic syndrome, lymphoma, bleeding disorders, blood infection or received bone marrow transplantation in the investigating hospitals from January 1, 2020, and collect basic information, diagnostic and treatment information, prognosis information, as well as medical expense information from medical records. In its current form, the NICHE registry incorporates historical data (collected from 2000) and is systematically collecting prospective data in two phases with broadening reach, and prospectively follow-up to collect the prognosis information.

Enrollment

2,300 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients who were diagnosed with acute myeloid leukemia, multiple myeloma, hemophilia, aplastic anemia, leukemia, myelodysplastic syndrome, lymphoma, bleeding disorders or received bone marrow transplantation in the investigating hospitals from January 1, 2020.

Exclusion criteria

Long-term follow-up information for patients is not available for any reason, such as not being available or having a serious concomitant disease.
Alcohol and drug addictions affect their ability to comply with study requirements.
According to the investigator, there are conditions that may endanger the patient's safety or affect his/her compliance.