Natriuretic Peptide's Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

Danish Headache Center

Status: Completed

Conditions: Migraine; Headache

Treatments: Drug: Natriuretic peptides

Study type: Interventional

Funder types: Other

Identifiers

NCT01637662

H-3-2012-065

Details and patient eligibility

About

To investigate headache score and accompanying symptoms during and after infusion of the natriuretic peptides.

Enrollment: 6 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy volunteers
• Aged 18-40
• 50-100 kg
• Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion criteria

• Tension type headache more than once/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 24 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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6 participants in 1 patient group

Healthy subjects

Experimental group

Treatment:

Drug: Natriuretic peptides