Natural Cycle In Vitro Fertilization

Reproductive Medicine Associates of New Jersey

Status: Completed

Conditions: Natural Cycle in Vitro Fertilization (IVF)

Study type: Observational

Funder types: Other

Identifiers

NCT01866618

RMA-2013-01

Details and patient eligibility

About

Natural IVF study patients will undergo an IVF cycle with trigger shots of Lupron & hCG. Patients will not be given any other stimulating medications during the cycle. They will have 2 uterine aspirations and an endometrial biopsy at designated times. The first uterine aspiration will be randomized to one of four days (day before retrieval, day of retrieval, day after retrieval or 2 days after retrieval). The second uterine aspiration and endometrial biopsy will be performed 6 days after retrieval. Any embryo(s) obtained will be biopsied for Comprehensive Chromosome Screening (CCS) and frozen for use in a subsequent thaw cycle.

Enrollment: 524 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ovulatory cycles every 39 days or less (natural cycle IVF cannot be performed in someone who does not have cycles)
• Must be RMANJ patient and have completed all diagnostic screening at one of our RMANJ locations. All diagnostic screening is NOT covered under the study and must be completed prior to being allowed to start the study cycle.

Exclusion criteria

• Prior enrollment/attempt in this study
• Requirement for surgical sperm extraction
• Inability to assess ovaries via transvaginal ultrasound
• Inability to tolerate vaginal examination

Trial design

524 participants in 1 patient group

Natural IVF Cycle

Description:

All patients will undergo a natural IVF cycle using trigger shots of Leuprolide Acetate(Lupron) and human chorionic gonadotropin (hCG) to ensure the patient surges.