Natural Cycle or Stimulated Cycle Versus Hormone Replaced Cycle for Pre-eclampsia Rate

Women's Hospital School Of Medicine Zhejiang University

Status: Unknown

Conditions: Pre-Eclampsia

Treatments: Other: hormone replaced cycle for endometrium preparation; Other: natural cycle for endometrium preparation

Study type: Interventional

Funder types: Other

Identifiers

NCT04310683

PREECLAMPSIA

Details and patient eligibility

About

Recent sutdies indicate that the existence of corpus lutein in the ovary is a key point to prevent preeclampsia, and patients undergoing FET with hormone replaced cycle have no corpus lutein and the absence of corpus lutein significantly increases the risk of preeclampsia in these patients. We aim to conduct a single center randomized trial study to compare the preeclampsia rate between the natural cycle and the hormone replaced cycle in patients undergoing FET.

Enrollment: 840 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18 to 42 years old women;
2. normal ovulation;
3. Scheduled to undergo frozen-thawed embryo transfer.
4. Agreeing with the informed consent.

Exclusion criteria

1. Those who experienced embryo transfer cycle failure for at least three times;
2. One or both of the ovaries removed;
3. Hypertention disease before embryo transfer;
4. No available embryo for transfer
5. Oocyte or sperm donated cycles

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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840 participants in 2 patient groups

natural cycle for endometrium preparation

Other group

Description:

patients will have ovulation before embryo transfer

Treatment:

Other: natural cycle for endometrium preparation

hormone replaced cycle for endometrium preparation

Experimental group

Description:

patients will do not have ovulation before embryo transfer

Treatment:

Other: hormone replaced cycle for endometrium preparation