Natural History of Mineral Metabolism Parameters and Protein-bound Toxins in Incident Peritoneal Dialysis Patients

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Complication of Peritoneal Dialysis

Study type: Observational

Funder types: Other

Identifiers

NCT01306149

FWO01-03-21

Details and patient eligibility

About

The aims of this study are

1. To evaluate the natural history of plasma concentrations and renal and peritoneal clearances of small water-soluble uremic retention molecules (URM), 'middle molecules', and protein bound URM in incident peritoneal dialysis (PD) patients.
2. To evaluate the natural history and determinants of the generation rate of URM originating from bacterial protein fermentation in PD patients.
3. To evaluate the natural history of biochemical parameters of mineral metabolism in incident PD patients.

Enrollment: 96 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Incident PD patients, defined as patients who started on PD as first renal replacement therapy less than 8 weeks before inclusion
• written informed consent
• age > 18 years old