Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers

The Chinese University of Hong Kong

Status: Completed

Conditions: Peptic Ulcer

Study type: Observational

Funder types: Other

Identifiers

NCT00153712

NNH Study

Details and patient eligibility

About

The aim of this study is to study the natural history of the ulcer healing while on proton pump inhibitors (PPI) and the ulcer recurrence without acid suppression therapy of Non-steroidal Anti-inflammatory Drugs (NSAID), non-Helicobacter pylori (HP) bleeding ulcer patients.

Full description

Non-steroidal Anti-inflammatory Drugs (NSAID), Non-Helicobacter pylori (HP) bleeding peptic ulcers are relatively common in the West (11%-44%). It is uncommon in Hong Kong (4%). Significant number of these patients with non-NSAID, non-Hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. Our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (NSAID), non-Helicobacter pylori (Hp) bleeding peptic ulcers. There is no datum on the natural course of these patients and this is our aim to have this observational study.

Enrollment: 391 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient has non-NSAID (non-steroidal anti-inflammatory drugs), non-Helicobacter pylori bleeding peptic ulcer
• Age > 18 years old
• Informed consent

Exclusion criteria

• Concommitant use of high dose steroid or warfarin
• New start on non-steroidal anti-inflammatory drugs or aspirin or COX2 inhibitors
• Renal failure (serum creatinine > 200umol/l)
• Previous gastric surgery
• Oesophagitis, esophageal varices
• Terminal illness or malignancy

Trial design

391 participants in 2 patient groups

Non NSAID non-Hp

Description:

Patient of history of peptic ulcer bleeding with Hp-ve and without prior history of taking NSAID or Aspirin within 30 days

Helicobacter pylori +ve

Description:

Patient with Hp+ve at peptic ulcer bleeding