Natural History of Oculo-Pharyngeal Muscular Dystrophy (OPMD) - Israel National OPMD Registry (Isr-OPMD)

Sheba Medical Center

Status: Enrolling

Conditions: Oculopharyngeal Muscular Dystrophy (OPMD)

Treatments: Other: Non-interventional observational study

Study type: Observational

Funder types: Other

Identifiers

NCT07146256

SHEBA-21-8801-AD-CTIL

Details and patient eligibility

About

The goal of this open prospective multi-disciplinary observational study of patients with OPMD at various stages of clinical manifestations is to explore the natural history of the disease in the Israeli population.

Full description

The the following procedures will be performed by a multidisciplinary team:

Neurological and neurocognitive examination; Clinical assessment of of swallowing and severity of dysphagia; Clinical assessment of eyelid ptosis severity; Clinical assessment of respiratory muscles function; Clinical assessment of oral health

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with clinical diagnosis of OPMD or patients with signs /symptoms suggestive of OPMD

Exclusion criteria

• Age <18 years and Pregnancy

Trial design

300 participants in 1 patient group

Subjects with genetically diagnosed OPMD

Treatment:

Other: Non-interventional observational study