Natural History of SMA (iSMAR)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Muscular Atrophy, Spinal

Study type: Observational

Funder types: Other

Identifiers

NCT05755451

1894

Details and patient eligibility

About

This is an investigator initiated observational study with the aim to record several aspects of function, care and adverse events in a large cohort of SMA patients followed longitudinally by using a structured academic disease registry.

Full description

This is an observational multicenter retrospective and prospective study involving high quality data collected in 5 academic centers in Italy, the registry aims to

• better understand the natural history of the disease in untreated patients identifying factors that can influence disease progression by combining retrospective and prospective data.
• Describe the patterns of disease progression (in terms of functional measure, adverse events, levels of care, and hospitalization) in treated and untreated patients
• Identify all the patients treated with the available therapies in Italy, providing first line details on epidemiological data in a wider network including all centers recognized as centers for spinal muscular atrophy (SMA) in each region.

As part of the activity clinical evaluators, data manager and sub-investigators are also trained and use common manuals of operation to ensure reliability across the participating centers. The registry provides accurate and reliable information on natural history including results from currently used functional measures. The registry also includes information on supportive care, hospitalization and adverse events.

Details of the electronic clinical file record including data assembly and the platform used are available as part of a peer reviewed paper

Enrollment: 1,200 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

all patients

Exclusion criteria

if enrolled in clinical trials