Natural History Study of Factor IX Treatment and Complications (B-Natural)

Skane University Hospital

Status: Unknown

Conditions: Factor IX Deficiency

Treatments: Other: Standard care with blood and urine sample collection

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02502409

B-Natural

Details and patient eligibility

About

This study will examine two groups of subjects with factor IX (FIX) deficiency: 1) those with a current or history of inhibitors to FIX, and; 2) groups of two or more affected brothers, with or without inhibitors. The overall goal is to characterize the study groups in terms of their medical history, their patterns of bleeding, their care, quality of life, and complications including the development of joint disease, inhibitory antibodies to FIX, use of immune tolerance induction (ITI) and outcome.

Full description

Hemophilia B, FIX deficiency, is the second most common type of hemophilia, occurring in about one in 25,000 male births. This disease is in some ways more complex than hemophilia A, and is less well understood. Differences include a lower incidence and a greater risk of side effects to treatment, for example, allergic reactions and kidney disease. This study will examine two groups of subjects with FIX deficiency - those with a current or history of inhibitors to FIX, and groups of two or more affected brothers, with or without inhibitors. The overall goal is to characterize the study group in terms of their medical history, their patterns of bleeding, their care, quality of life, and complications including the development of inhibitory antibodies to FIX, allergies, kidney, and joint disease.

Enrollment: 550 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. A consent approved by the appropriate Institutional Review Board (IRB)/Independent Ethics Committee (IEC) has been obtained from the subject or his legally acceptable representative

2. Subject has FIX deficiency AND

   • Is part of an affected brother pair/group that will also enroll; AND/OR
   • Has a current or history of inhibitor, defined as >0.6 Bethesda units (BU)

Exclusion criteria

1. Subject has another congenital bleeding disorder
2. Subject is a carrier of hemophilia B with factor level >0.40 IU/mL