NAV-ALI: Neurally Adjusted Ventilatory Assist in Patients Recovering Spontaneous Breathing After Acute Lung Injury

Caen University Hospital

Status: Completed

Conditions: Acute Lung Injury; Mechanical Ventilation

Treatments: Device: NAVA - EMG; Device: NAVA - Neurally Adjusted Ventilatory Assist; Device: PSV - pressure suppot ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT00963066

2009-A00583-54

Details and patient eligibility

About

Evaluation of a new ventilatory mode Neurally Adjusted Ventilatory Assist "NAVA" in patients who recover spontaneous breathing after acute lung injury.

Full description

Physiological evaluation of two modes of mechanical ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation, at different levels of ventilator assistance.

Evaluation in term of physiological parameters: Tidal volume, Respiratory rate, Inspiratory effort, PaCO2, evaluation of subject-ventilator synchrony.

Evaluation of physiological response to varying levels of ventilator assistance.

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Hospitalized in intensive care unit
• Acute Lung Injury
• Intubated or tracheotomized and mechanically ventilated

Exclusion criteria

• Hemodynamic instability
• Absence of consent

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15 participants in 3 patient groups

Pressure Support ventilation

Active Comparator group

Treatment:

Device: PSV - pressure suppot ventilation

NAVA flow triggering

Experimental group

Description:

Spontaneous Breathing using Neurally Adjusted Ventilatory Assist with flow triggering

Treatment:

Device: NAVA - Neurally Adjusted Ventilatory Assist

NAVA EMG triggering

Experimental group

Description:

Spontaneous Breathing using Neurally Adjusted Ventilatory Assist with trigger adjusted on diaphragmatic electromyogram

Treatment:

Device: NAVA - EMG