"NAVA-PAV" Study: a Cross-over Comparative Study of 2 Advanced Modes

University Hospital Center (CHU)

Status and phase

Completed

Phase 3

Conditions

Ventilation Weaning

Critical Illness

Mechanical Ventilation

Intensive Care

Treatments

Other: PAV+ ventilatory mode

Other: NAVA ventilatory mode

Study type

Interventional

Funder types

Other

Identifiers

NCT01607723

UF 8916

Details and patient eligibility

About

Neurally adjusted ventilatory assist (NAVA) and Proportional Assist Ventilatory Plus (PAV +) are new modes of mechanical ventilation that delivers ventilatory assist in proportion to the electrical activity of the diaphragm for NAVA and to patients efforts for PAV +. The goal of this trial is to compare oxygenation,ventilator comfort, patients -ventilator asynchronies, and sleep pattern between NAVA and PAV+.

Full description

Twenty patients will be enrolled. They will be ventilated with PAV+ and NAVA for one day, each in a randomized crossover order. The oxygenation,ventilator comfort, patients -ventilator asynchronies, and sleep pattern will be compared.

Enrollment

13 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Estimated remaining duration of mechanical ventilation for more than two days
patient alert and calm
Surrogate decision maker's consent

Exclusion criteria

Clinical contraindication for the use of NAVA: contraindications for an EAdi catheter placement (e.g., esophageal varices, upper gastrointestinal bleeding, gastroesophageal surgery)
Clinical instability for any reason
Contraindications for continuing intensive care treatment
Patient under tutelage
Age < 18 years
Pregnancy
No French health insurance