NAVADYN11 : Hemodynamic Impact of a New Ventilatory Support Mode With Diaphragmatic Synchronization

Nantes University Hospital (NUH)

Status

Terminated

Conditions

Invasive Ventilatory Support

Treatments

Other: collection of clinical and biological parameters

Other: assign optimal ventilatory mode

Study type

Interventional

Funder types

Other

Identifiers

NCT01490710

11/6-H

Details and patient eligibility

About

Despite spectacular advances since the 90s mechanical ventilation used in intensive care units are amply associated with cardio-respiratory complications: nosocomial pneumonia, lung parenchyma lesions induced by ventilation, hemodynamic instability and ultimately to a significant morbidity and mortality.

NAVA (Neurally Adjusted Assist Ventilation) ventilatory support, provides synchronous support, proportionate to patient's respiratory efforts. More "physiological", this mode would decline its efficacy on patient hemodynamic response. However, to date, no study has focused on hemodynamic impact of NAVA. This is precisely the purpose of NAVADYN11 study, which aims to assess NAVA efficacy on cardiac index in pediatric intensive care unit.

Enrollment

9 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Servo-i with NAVA available at patient admission
Sedation protocol compatible with NAVA functioning
Parental consent

Non inclusion criteria:

Digestive pathology incompatible with gastric tube.
Deep sedation required defined by score ComfortB <11 (cranial traumatism...)
Brain damage incompatible with spontaneous ventilation
Duration of intubation too short for investigation

Exclusion criteria

Clinical worsening requiring treatment and/or management inconsistent with NAVADYN11 research (CPR, emergency surgery ...). However, the investigator is allowed to reiterate investigation when patient stabilized.