NAVASET: Nava Level Titration Using Comfort Scales

Caen University Hospital

Status: Unknown

Conditions: Acute Respiratory Failure

Treatments: Device: Neurally Adjusted Ventilatory Assist; Device: PSV - pressure support ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT02133443

2013-A01835-40 (Other Identifier)

Details and patient eligibility

About

Determining the optimal Neurally Adjusted Ventilatory Assist (NAVA) level remains challenging, and several methods have been suggested. However none of them seems easily utilisable. Thus the investigators propose to test a way of NAVA level titration according to ventilator comfort.

Full description

Physiological comparison of different levels of ventilator assistance during Neurally Adjusted Ventilatory Assist (NAVA) to evaluate the effect of these on tidal volume, inspiratoy activity, comfort scales.

We propose to evaluate the ability to guide the titration according the patient's comfort scale. The intensity of the breathing sensations will be evaluated using the labeled visual analog scale (Banzett Scale).

Enrollment: 15 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years
• Hospitalized in intensive care unit for an acute respiratory failure
• Intubated or tracheotomized and mechanically ventilated
• RASS score: 0;-2
• Weaning period

Exclusion criteria

• Hemodynamic instability
• Absence of consent
• Contraindication of nasogastric catheter insertion

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Pressure Support Ventilation

Active Comparator group

Description:

Device: PSV - pressure support ventilation

Treatment:

Device: PSV - pressure support ventilation

Neurally Adjusted Ventilatory Assist

Active Comparator group

Description:

Device: Partial ventilator support with partial ventilation mode (NAVA)

Treatment:

Device: Neurally Adjusted Ventilatory Assist