Navigated Brain Stimulation in Diagnosis of Minimally Conscious State (C-fMRI-NBS)

Clinical Institute of the Brain, Russia

Status: Completed

Conditions: Vegetative State; Brain Injury; Stroke

Treatments: Device: Navigated transcranial magnetic brain stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT01467908

C-fMRI-NBS

Details and patient eligibility

About

It has already been demonstrated that mental imagining of the complex motor act, such as limb lifting, can evoke the activation of the involved motor centres even if it doesn't result in movement due to paresis. Aim of the study: using the navigated brain stimulation system create a new diagnostic model for the differential diagnostics between the vegetative state and the minimally conscious state. If the investigators could get from patient the efferent motor response after a verbal command, his level of conscious should not be defined less than the minimally conscious state.

Enrollment: 6 patients

Sex: All

Ages: 20 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed vegetative state
• age 20-85

Exclusion criteria

• oncological history
• cardiac pacemakers and other metal implants
• Modified Ashford Scale scores 3 and more
• predisposing disease with motor neurologic impairment

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

Vegetative state

Experimental group

Description:

Patients with the diagnosis of the vegetative state

Treatment:

Device: Navigated transcranial magnetic brain stimulation