Near Normalisation of BG Improves the Potentiating Effect of GLP-1

Hvidovre University Hospital

Status: Completed

Conditions: Diabetes Mellitus Type 2

Treatments: Drug: Saline; Drug: glucagon-like peptide-1

Study type: Interventional

Funder types: Other

Identifiers

NCT00612625

KF 01 - 198/03

KA 01 - 198/03

Details and patient eligibility

About

The ability of glucagon-like peptide 1 to enhance beta-cell responsiveness to I.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near-normalisation og blood glucose improves the potentiation of glucose-stimulated insulin secretion by GLP-1

Enrollment: 9 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-70 years
• Type 2 diabetes diagnosed after 30 years of age
• BMI > 25

Exclusion criteria

• Severe complications to diabetes
• Abnormal liver og kidney function
• Haemoglobin below the lower limit
• Macroalbuminuria
• Systemic disease
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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9 participants in 2 patient groups

GLP-1

Experimental group

Description:

A graded glucose infusion with an infusion of GLP-1 (1½ pmol/kg/min)

Treatment:

Drug: glucagon-like peptide-1

Saline

Experimental group

Description:

A graded glucose infusion together with a continuous infusion of saline

Treatment:

Drug: Saline