Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure (CARNEBI)

Centro Cardiologico Monzino

Status and phase: Completed; Phase 4

Conditions: Chronic Heart Failure

Treatments: Drug: carvedilol; Drug: Nebivolol; Drug: bisoprolol

Study type: Interventional

Funder types: Other

Identifiers

NCT00517725

R76-CCM S78/407

Details and patient eligibility

About

The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.

Both could influence exercise capacity in normoxic as well as hypoxic conditions.

Enrollment: 60 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic heart failure patients in stable clinical condition

Exclusion criteria

• No comorbidity
• NYHA class IV

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Carvedilol

Active Comparator group

Treatment:

Drug: carvedilol

Bisoprolol

Active Comparator group

Treatment:

Drug: bisoprolol

Nebivolol

Active Comparator group

Treatment:

Drug: Nebivolol