Neck Cooling as a Non-Invasive Method to Lower Brain Temperature in Healthy Adults

University of Vermont

Status

Completed

Conditions

Healthy

Treatments

Device: Cold circulated water

Device: Body-temperature circulated water

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT04973085

STUDY00001312

Details and patient eligibility

About

The objective of this study was to clarify whether neck cooling can be used to non-invasively lower brain temperature in healthy adults.

Full description

Healthy adults were randomized to undergo an intervention in which either cold or body-temperature water was circulated through an adhesive wrap applied to the front of their necks, overlying the carotid arteries, for 120 minutes. After their first intervention, subjects crossed over (i.e., cold went to body-temperature, and vice-versa) on a separate day. Brain temperature was measured in one-minute intervals using MR thermometry.

Enrollment

22 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy adults aged 18-65 years

Exclusion criteria

Pregnancy
Contraindications to MRI (e.g. claustrophobia, metallic implants, etc.)
Signs of ulcerations, burns, hives or rash where the neck wrap is applied
History of Raynaud's disease, venous or arterial occlusive disease (e.g. carotid stenosis), cryoprecipitation disorders (e.g. cryoglobulinemia) and pernio (also known as chilblains)