Necrotizing Bacterial Dermohypodermitis-necrotizing Fasciitis Mono- or Multi-microbial Streptococcus Beta-haemolytic (STREPTO-FAST)

Assistance Publique - Hôpitaux de Paris

Status: Unknown

Conditions: Streptococcus Infection

Treatments: Other: DHBN-FN arm; Other: Control arm (Erysipelas)

Study type: Interventional

Funder types: Other

Identifiers

NCT03976024

APHP180348

Details and patient eligibility

About

The aim of the study is to evaluate streptococcal carriage by swab, pharyngeal, anal and perineal in patients with DHBN-FN, in the entourage living under the same roof as well as patients with erysipelas

The main hypothesis is the major role of chronic porting of patients and entourage in DHBN-FN to SBH.

Indeed, the chronic pharyngeal / anal / perineal carriage could be a gateway following a transient bacteremia for a DHBN-FN.

The transmission of germs from the surrounding to the patient plays a major role:

At the gateway level in the case of exogenous DHBN-FN At the origin of chronic carriage in the case of endogenous DHBN-FN Transmission of germs from the patient to the surrounding area also plays an important role in increasing the risk of invasive SBH infections in the surrounding area.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient:
• Major patient hospitalized for a DHBN-FN or erysipelas (clinical diagnosis determined at the entrance).
• Signed informed consent.

Case contact

• person of major age living under the same roof as a patient who has had a DHBN-FN.
• Signed informed consent

Exclusion criteria

• Patient:
• Minor patient
• Immunosuppressed patient: active hematology, poorly controlled HIV, neutropenia (PNN <1000 / mm3).
• Patient under guardianship or curatorship
• Patient deprived of liberty by judicial or administrative decision
• Patient not affiliated to a social security scheme and not a beneficiary of such a scheme

Case contact

• Minor person
• Person under tutorship or curatorship
• Person deprived of liberty by judicial or administrative decision
• Person not affiliated with a social security

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

DHBN-FN arm

Experimental group

Description:

Recruitment is planned in traditional hospitalization for DHBN-FN patients. Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN at the end of hospitalization and 1 month after discharge from hospital during the reassessment consultation. Swabs made by the dermatologist. The carriage of streptococcus in patients living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal swab, anal and perineal. If the family accepts, the carriage of streptococcus in persons living under the same roof as patients with DHBN-FN will be evaluated by pharyngeal, anal and perineal swab in consultation. These swabs will be made within 10 days of diagnosis of DHBN-FN of the index

Treatment:

Other: DHBN-FN arm

Control arm (Erysipelas)

Active Comparator group

Description:

Recruitment is planned in traditional hospitalization for patients with erysipelas. The carriage of streptococcus in patients with erysipelas will be evaluated by pharyngeal, anal and perineal swab on day 0 (admission).

Treatment:

Other: Control arm (Erysipelas)