Necrotizing Enterocolities

Assiut University

Status

Not yet enrolling

Conditions

Necrotizing Enterocolitis of Newborn

Treatments

Other: Complete blood count

Study type

Observational

Funder types

Other

Identifiers

NCT06632041

Necrotizing enterocolities

Details and patient eligibility

About

Haematological disturbances in neonates with necrotizing enterocolities

Full description

Necrotizing enterocolitis (NEC) is an acquired, multifactorial and devastating gastrointestinal disease associated with high morbidity and mortality in preterm neonates. With an incidence of about 7% in infants with BW < 1500 g and mortality up to 30%, NEC presents as a medical and surgical emergency It is characterized by ischemia, necrosis, and inflammation of bowel wall with invasion by gas-forming organisms and intramural dissection of gas ,characteristicall appearing as pneumatosis intestinalis in radiological and pathological studies. While exact etiology is undetermined, the pathogenesis is believed to be an anomalous innate immune response to an altered, less diverse intestinal microbiota by the highly immunoreactive enterocytes of premature infants, leading to inflammation and tissue necrosis

in this devastating disease with undetermined etiology. Breast milk feeding, prolonging gestation to avoid prematurity, antenatal steroid, and the use of probiotics/prebiotics are established prevention strategies in NEC
The hematological abnormalities associated with NEC were first described 25 years ago by Hutter et al.The abnormalities observed in a series of 40 patients with NEC included thrombocytopenia, with
and without disseminated intravascular coagulation (DIC), neutrophilia or neutropenia, and hemolytic anemia.

Enrollment

70 estimated patients

Sex

All

Ages

1 to 30 days old

Volunteers

No Healthy Volunteers

Inclusion criteria