NEFA (Non Esterified Fatty Acid) , Adipose Factors Behind Insulin Sensitivity

Karolinska Institute

Status: Completed

Conditions: Non-obese Controls; Obesity

Treatments: Other: Obese; Other: Control group

Study type: Interventional

Funder types: Other

Identifiers

NCT01727245

2011/1002-31/1

Details and patient eligibility

About

We want to asses the role of adipose tissue for metabolic complications to obesity before and after weight loss (surgery).

Enrollment: 500 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria obese:

• Bariatric surgery with laparoscopic gastric by-pass

Exclusion Criteria obese:

• diabetes mellitus typ 2 with insulin treatment and/or glitazones
• oral or parenteral steroid treatment
• complicated psychiatric disease
• Warfarin use

Inclusion Criteria non-obese controls:

• BMI under 30

Exclusion Criteria non-obese controls:

• diabetes
• oral or parenteral steroids treatment
• complicated psychiatric disease
• Warfarins use

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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500 participants in 2 patient groups

Obese

Other group

Description:

Obese patients undergoing gastric by-pass surgery

Treatment:

Other: Obese

Control group

Other group

Description:

Cholecystectomy and anti-reflux surgery

Treatment:

Other: Control group