Nefopam as a Multimodal Analgesia for Thoracic Surgery

Kangbuk Samsung Hospital

Status: Completed

Conditions: Lung Cancer

Treatments: Drug: Nefopam

Study type: Interventional

Funder types: Other

Identifiers

NCT05173337

NEVATS2

Details and patient eligibility

About

Acute postoperative pain after video-assisted thoracoscopic surgery is very severe. Because pain after thoracic surgery prevents early recovery, and increases postoperative complications, its is important to prevent pain after video-assisted thoracoscopic surgery. In the present study, we will evaluate whether nefopam reduces pain after video-assisted thoracoscopic surgery.

Enrollment: 46 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient scheduled for elective video-assisted thoracoscopic surgery
• American Society of Anesthesiologists physical grade I, II, III
• patient aged from 18 years old

Exclusion criteria

• history of allergy in nonsteroidal anti-inflammatory drugs, or nefopam
• renal insufficiency
• liver insufficiency
• myocardial infarction
• glaucoma
• pregnant and lactating women at the time of surgery
• patient who did not consent to the use of patient-controlled analgesia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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46 participants in 2 patient groups

control group

No Intervention group

Description:

Nefopam will not be administered in this group.

nefopam group

Experimental group

Description:

Intravenous nefopam 20 mg will be administered twice, immediately after induction of anesthesia and at the end of surgery.

Treatment:

Drug: Nefopam