ClinicalTrials.Veeva

Menu

Nefopam for Post Video-Assisted Thoracoscopic Lobectomy

M

Mahidol University

Status and phase

Completed
Phase 4

Conditions

Pain, Postoperative

Treatments

Drug: Nefopam 20 MG/ML
Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT04241640
SI 001/2020

Details and patient eligibility

About

Video-assisted thoracoscopic (VATs) lobectomy is mild to moderately pain procedure. For conventional thoracotomy, there are many invasive pain control such as epidural analgesia, paravertebral block. However, for VATs, the invasive pain control somehow are too invasive. Nefopam is non-opioid painkilling medication, Serotonin, norepinephrine, dopamine reuptake inhibitor. Many study were demonstrated positive outcome of nefopam usage in many operation such as abdominal surgery, laparocopic surgery, orthopedic surgery. Nevertheless, nefopam for VATs is not well studied yet.

Enrollment

72 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Schedule to video-assisted thoracoscopic surgery : VATs lobectomy
  • Can operate a patient-controlled analgesia (PCA) device
  • No contraindication for nefopam

Exclusion criteria

  • Epilepsy, on monoamine oxidase (MAO) inhibitors, glaucoma
  • Creatinine clearance < 60 ml/min
  • Liver disease: child-pugh score B or C
  • Allergy to nefopam
  • Chronic opioid use

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

72 participants in 2 patient groups, including a placebo group

Nefopam group[
Experimental group
Treatment:
Drug: Nefopam 20 MG/ML
placebo group
Placebo Comparator group
Treatment:
Drug: Placebo

Trial contacts and locations

1

Loading...

Central trial contact

Chaowanan Khamtuikrua, MD; Sirilak Suksompong, MD

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems