Negative Postprandial Effect on Endothelium After a Not-healthy Meal in Type 2 Diabetes as Affected by Training

Norwegian University of Science and Technology

Status: Completed

Conditions: Diabetes Mellitus, Type 2

Treatments: Behavioral: exercise healthy volunteers; Behavioral: control; no exercise training; Behavioral: 47 min moderate intensity training

Study type: Interventional

Funder types: Other

Identifiers

NCT01991769

2011/1801

Details and patient eligibility

About

The purpose of this study is to examine whether exercise reduces the postprandial effects of an unhealthy meal on heart function and endothelial function.

Both healthy people and type 2 diabetes subjects will during three days either carry out two different sessions of exercise training or not before ingesting an unhealthy meal high in saturated fat and fast carbohydrates. The two different exercise training modes used are high intensity interval training (HIIT) and moderate intensity training (MIT) Hypothesis: Exercise training in advance of an unhealthy meal will improve endothelial- and cardiac function in healthy and type 2 diabetes individuals. HIIT will reduce the negative postprandial effects on the endothelium more than MIT.

Enrollment: 20 patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• healthy or type 2 diabetes

Exclusion criteria

• type 2 diabetes more than 10 years
• unstable angina
• myocardial infarction
• overt cardiovascular disease.
• severe valvular disease.
• overt lung disease.
• orthopedical- /neurological restrictions
• severe disease related to diabetes type 2 (neuropathy, micro-or macroalbuminuria, retinopathy)
• body mass index >35
• severe eating disorders.
• personality disturbances.
• planned surgery during the project period.
• patients who achieve greater than the current exercise guidelines for type 2 diabetes (210 min/week) before the start of the study.
• uncontrolled hypertension
• kidney failure
• cardiomyopathy
• smoking
• patients who probably not will be able to complete the study
• alcohol or drug abuse

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups

exercise diabetes type 2

Experimental group

Description:

4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.

Treatment:

Behavioral: exercise healthy volunteers

Behavioral: control; no exercise training

Behavioral: 47 min moderate intensity training

exercise healthy volunteers

Active Comparator group

Description:

4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.

Treatment:

Behavioral: exercise healthy volunteers

Behavioral: control; no exercise training

Behavioral: 47 min moderate intensity training