Neoadjuvant Chemotherapy With Nab-paclitaxel Plus Cisplatin for Stage Ⅱ-Ⅲ Esophageal Cancer Patients (nabPCESCC)

University of Chinese Academy Sciences

Status and phase

Completed

Phase 2

Conditions

Esophageal Squamous Cell Carcinoma

Treatments

Drug: albumin-bound paclitaxel plus cisplatin

Study type

Interventional

Funder types

Other

Identifiers

NCT01258192

ZhejiangCH-ESCC-01

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy and safety of neoadjuvant chemotherapy with nab-paclitaxel plus cisplatin for stage Ⅱ-Ⅲ esophageal squamous cell carcinoma patients.

Full description

A surgical resection is currently the preferred treatment for esophageal cancer if the tumor is considered to be resectable without evidence of distant metastases.A higher percentage of radical resection is reported in studies using neoadjuvant chemotherapy followed by surgery versus surgery alone.The neoadjuvant chemotherapy may improve overall survival. Neoadjuvant chemotherapy with administrations of paclitaxel combined with cisplatin or carboplatin has shown effectively.Nanoparticle albumin-bound (nab)-paclitaxel has better efficacy and practically eliminates the risk of hypersensitivity reactions associated with solvent-based paclitaxel.We try to evaluate the efficacy and safety of neoadjuvant chemotherapy with nab-paclitaxel plus cisplatin for stage Ⅱ-Ⅲ esophageal squamous cell carcinoma patients.

Enrollment

35 patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologic diagnosis of squamous cell carcinoma of esophagus. Preoperative stage Ⅱ-Ⅲ by endoscopic ultrasound, CT of the chest and abdomen,and esophagogram.
Age ranges from 18 to 70 years.
Patients must not have received any prior anticancer therapy.
Performance status of 0 to 1
Estimated life expectancy of at least 6 months.
Tumor can be measured according to RECIST criteria
Signed informed consent document on file.
Females with childbearing potential must have a negative serum pregnancy
Adequate organ function including the following:

Bone marrow: Absolute neutrophil count (ANC) greater than or equal 1.5×109/L Platelets greater than or equal 80×109/L Haemoglobin greater than or equal 80g/L Hepatic: total bilirubin less than or equal to 1.5 times upper limit of normal (ULN), Alanine transaminase (ALT) and aspartate transaminase (AST) less than or equal to 2.5 times ULN Renal: calculated creatinine clearance rate≥60ml/min. test within 7 days prior to study enrollment.

Exclusion criteria

Carcinoma at the upper part of esophagus
Histologic diagnosis of adenocarcinoma of esophagus.
Prior treatment for esophageal cancer.
Active infection.
Pregnant or breast feeding.
History of significant neurological or mental disorder, including seizures or dementia.
Prior invasive malignancy in 5 years (except for carcinoma in situ).