Neonatal Hypoxic Ischemic Encephalopathy : Safety and Feasibility Study of a Curative Treatment With Autologous Cord Blood Stem Cells (NEOSTEM)

Public Assistance-Hospitals of Marseille (AP-HM)

Status and phase

Enrolling

Phase 2

Phase 1

Conditions

Neonatal Hypoxic-ischaemic Encephalopathy

Treatments

Drug: autologous cord blood stem cell

Study type

Interventional

Funder types

Other

Identifiers

NCT02881970

2013-A01018-37

2013-32

Details and patient eligibility

About

Neonatal hypoxic-ischaemic encephalopathy is a dramatic perinatal complication due to brain asphyxia. Neurological and neurosensory sequelae are frequent in survivors, due to neuronal damage and loss.

Currently, only total or partial body hypothermia can partially prevent cell loss. However, no treatment exists to restore neuronal functions.

Cord blood stem cells are a promising treatment for the near future.

The primary objective of this study is to test the safety and feasibility of a curative treatment with autologous cord blood stem cell in neonatal hypoxic-ischaemic encephalopathy.

The secondary objectives are to test the efficacy of this curative treatment with cell with neurogenic potential on the prevention of neurologic sequelae, as well as to test the optimum timing of cell preparation administration

Enrollment

20 estimated patients

Sex

All

Ages

1 to 3 days old

Volunteers

No Healthy Volunteers

Inclusion criteria

Term ≥ 36 weeks of gestation

and (2) :
a blood pH < 7 with base deficit > 12 mmol/l (at birth or within 60 minutes of age)
or a blood pH between 7,01 and 7,15, with additionnal criteria:
a history of acute perinatal event (e.g : abnormal fetal cardiac rate, cord prolapse, uterine rupture, maternal hemorrhage)
and a 5 minutes Apgar score ≤ 5, or a continued need for resuscitation, including endotracheal or mask ventilation at 5 min after birth.
signs of encephalopathy within 12 hours of age (Sarnat and Sarnat classification, score ≥ 2)
± abnormal electroencephalogram or aEEG within 12 hours of age
therapeutic hypothermia.
no maternal infection with VIH, HTLV 1 or 2, Hepatitis B or C virus.
maternal negative serology for syphilis
written parental consent

Exclusion criteria

presence of known chromosomal anomaly.
presence of major congenital anomalies. severe intrauterine growth restriction (weight <1800g)
infants in extremis for whom no additional intensive therapy will be offered by attending neonatologist.