Nerve Block Vs Sedation Infusion for Awake Fiberoptic Intubation.

Cairo University (CU)

Status: Completed

Conditions: Anticipated Difficult Airway; Dexmedetomidine; Sedation; Hemimandibulectomy; Superior Laryngeal Nerve Block; Awake Fiberoptic Intubation

Treatments: Drug: Dexmedetomidine; Drug: Superior laryngeal nerve block

Study type: Interventional

Funder types: Other

Identifiers

NCT06651905

MS-484-2023

Details and patient eligibility

About

This study compares the efficacy and safety of dexmedetomidine infusion versus superior laryngeal nerve block during awake fiberoptic intubation in hemimandibulectomy patients.

Enrollment: 80 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age range ≥ 18 or ≤60.
• Both sexes.
• American Society of Anesthesiologists (ASA) II-III.
• Body mass index:18.5 to 30 kg/m2.
• Hemimandibulectomy patients with an anticipated difficult airway [El-Ganzouri Risk Index (EGRI)>3].

Exclusion criteria

• Patient's refusal.
• Known allergy to drugs used in the study.
• Neurological disorders.
• Advanced liver or kidney disease.
• Patient with psychiatric disorders.
• Patient who needs postoperative ICU.
• Airway distortion and cervical spine movement.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Dexmedetomidine group

Experimental group

Description:

Patients were given 0.5 mcg/kg of dexmedetomidine over 10 minutes via a syringe pump, followed by a maintenance dose of 0.2-0.7 mcg/kg/hour until the end of intubation based on Hemodynamics.

Treatment:

Drug: Dexmedetomidine

Superior laryngeal nerve block group

Active Comparator group

Description:

Patients received an airway nerve block through bilateral superior laryngeal nerve block and trans-tracheal injection for recurrent laryngeal nerve.

Treatment:

Drug: Superior laryngeal nerve block