Nerve Composition of Human Lumbar Dorsal Primary Rami and Its Medial Branch

University of Aberdeen

Status: Enrolling

Conditions: Nerve Degeneration; Lumbar Facet Arthrosis

Treatments: Procedure: Spinal surgery; Other: Histology

Study type: Observational

Funder types: Other

Identifiers

NCT05091112

1-076-21

Details and patient eligibility

About

The purpose of the study is to understand the composition of the nerves supplying the facet joints in low back.

Full description

After written informed consent, the nerves supplying the facet joints - lumbar dorsal rami and its medial branches, will be harvested when they are exposed during spinal surgery. These nerves will be fixed, washed and further dissected to enable smaller sections. The cut section will be stained and subjected to analysis of overall cross-sectional area and presence of connective tissue sheaths under light microscope.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Be aged 18 or over
• be able to give informed consent
• scheduled to undergo lumbar spinal surgery

Exclusion criteria

• Children under 18 years old
• Vulnerable adults
• Adults with incapacity
• Inability to provide informed consent
• History of previous spinal surgery
• history of previous RF ablation for low back pain
• has COVID-19 or displaying symptoms of COVID-19

Trial design

20 participants in 1 patient group

Active group

Description:

Patients who are scheduled to undergo lumbar spinal surgery and fulfill the inclusion and exclusion criteria

Treatment:

Other: Histology

Procedure: Spinal surgery