Netrin-1 and Placenta Accreta

Assiut University

Status

Completed

Conditions

Placenta Accreta

Treatments

Other: at delivery

Other: Pregnant women at 28-32 weeks

Study type

Interventional

Funder types

Other

Identifiers

NCT04683562

PA-NT1

Details and patient eligibility

About

Netrin-1 is a secreted protein, which was first identified as a neuronal guidance factor. It is expressed in a multitude of tissues as pancreas, lung, breast, and placenta. Netrin-1 is a multifunctional protein, involved in cell polarity, adhesion, angiogenesis, apoptosis, migration, morphogenesis, and differentiation of various cell types. Most of netrin-1 activity occur through signaling pathways induced by its two main receptors, DCC (deleted in colorectal cancer) and UNC5H (uncoordinated-5 homolog). Its receptors have been linked to the processes of apoptosis and angiogenesis. In absence of netrin-1, DCC and UNC5H receptors lead to apoptosis. In contrary, in presence of netrin-1, receptors transduce molecular cascades leading to proliferation, differentiation and migration of the cells. Netrin-1 has been involved in the pathogenesis of multiple diseases, as diabetes, cardiovascular diseases, and cancer. Serum Netrin-1 levels were high in preeclamptic patients.

Enrollment

34 patients

Sex

Female

Ages

20 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age between 20-40 years.
Singleton pregnancy.
Women with suspicion of PA by two-dimensional (2D) gray scale imaging and color Doppler flow mapping

Exclusion criteria

Multiple pregnancy,
Fetal anomalies,
Preterm premature rupture of membranes, or infection
Any medical disorders, such as thyroid dysfunction, hypertension, and gestational diabetes
Patients with known bleeding disorders or on anticoagulant therapy.