Netrin-1 & Hepatocellular Carcinoma HCC (HCC-Net)

Civil Hospices of Lyon

Status: Unknown

Conditions: HCC

Treatments: Procedure: Quantification of netrin-1 signals by antibody-based approaches

Study type: Observational

Funder types: Other

Identifiers

NCT04766736

69HCL19_0258

Details and patient eligibility

About

Netrin-1 is a dependence receptor ligand participating in the pathology of several cancer types. It is up-regulated in chronic liver diseases, cirrhosis and HCC. We hypothesize that netrin-1 may play a detrimental role in HCC. The goal of this project is to characterize netrin-1 signals in HCC samples with ad hoc controls, to investigate the benefit of capturing netrin-1 in preclinical models of HCC and to try to define patients groups the most likely to benefit from this targeting approach in the clinic.

Enrollment: 320 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• any patient suffering from HCC
• age >18
• informed consent provided

Exclusion criteria

• absence of informed consent

Trial design

320 participants in 2 patient groups

Tumors (T) samples of various etiologies (HBV, HCV, NASH, alcool)

Description:

The combination of the Tumors status of the sample combined with its etiology ((HBV, HCV, NASH, alcool)

Treatment:

Procedure: Quantification of netrin-1 signals by antibody-based approaches

Non Tumors (NT) samples of various etiologies (HBV, HCV, NASH, alcool)

Description:

The combination of the Non Tumors status of the sample combined with its etiology ((HBV, HCV, NASH, alcool)

Treatment:

Procedure: Quantification of netrin-1 signals by antibody-based approaches