Nettle and Cranberry Capsules for Prevention of Urinary Tract Infection

Chung Shan Medical University

Status: Completed

Conditions: Urinary Tract Infection

Treatments: Dietary Supplement: Placebo(starch); Dietary Supplement: Nettle and Cranberry complex capsules

Study type: Interventional

Funder types: Other

Identifiers

NCT05880602

CS2-23025

Details and patient eligibility

About

This study investigates whether the oral intake of a nettle and cranberry complex capsule may prevent recurrent urinary tract infection (rUTI). Participants will be aged between 30 - 75 years of age, with confirmed diagnosis of UTI status. The participants will be assessed for several parameters and asked to take 2 nettle and cranberry complex capsules twice daily for 8 weeks. The parameters will include international prostate symptoms score (IPSS), overactive bladder symptom score (OABSS), international consultation on incontinence questionnaire - overactive bladder (ICIQ-OAB), 3-day bladder diary (3dBD), and urine routine.

Full description

Urinary tract infections (UTIs) are one of the most common bacterial infections affecting women. UTI occurs in 50-80% of women in the general population. About one in four women with one UTI episode will go on to develop frequent recurrences.

Recurrent urinary tract infection (rUTI) is defined as repeated UTI with a frequency of at least two episodes in the preceding six months or three episodes in the past year. rUTI has been regarded as a substantial global healthcare problem.

This investigation is a randomized, double-blind study. Subjects with confirmed diagnosis of rUTI are randomly assigned to control group or treatment group, and asked to orally intake 2 capsules of either placebo or nettle and cranberry complex capsules twice daily. Participants will be assessed for parameters, including international prostate symptoms score (IPSS) (male only), overactive bladder symptom score (OABSS), international consultation on incontinence questionnaire - overactive bladder (ICIQ-OAB), 3-day bladder diary (3dBD) and urine routine. The assessments are conducted at baseline, 4 weeks, and 8 weeks after the oral intake period. The parameters are used to compare and evaluate whether the nettle and cranberry complex capsule can prevention rUTI.

Enrollment: 60 patients

Sex: All

Ages: 30 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged between 30 and 75 years
• at least two episodes in 6 months, or at least three episodes of a UTI in 12 months.

Exclusion criteria

• pregnancy women
• diabetes
• History of anatomical urogenital anomalies, urogenital tract surgery
• History of acute or chronic renal failure, nephrolithiasis
• History of intestinal diseases causing malabsorption
• Anticoagulant medication in the last month
• immunocompromise
• Known allergy or intolerance to cranberry

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 2 patient groups, including a placebo group

Control

Placebo Comparator group

Description:

Subjects will take two capsule of containing starch, twice a daily for 8 weeks.

Treatment:

Dietary Supplement: Placebo(starch)

Treatment

Experimental group

Description:

Subjects will take two capsule of containing nettle and cranberry complex, twice a daily for 8 weeks.

Treatment:

Dietary Supplement: Nettle and Cranberry complex capsules