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This study will examine the neural mechanisms underlying both spontaneous behavior change and behavior change in response to a brief intervention among problem drinkers.
Full description
Although problem drinkers (PD) are a less severe, highly prevalent sub-type of alcohol use disorder (AUD) who are more likely to undergo reductions in alcohol use, compared to more severe AUD, the underlying mechanisms that maintain PD, as well as the mechanisms that underlie both spontaneous and treatment- related behavior change in this population, are not well understood. This proposal takes a lab to life approach by combining functional neuroimaging (fMRI), ecological momentary assessment (EMA), and brief interventions (BI) in non-treatment seeking PD to test whether heightened incentive salience (reactivity) to alcohol cues and impaired ability to regulate cue-induce craving are the mechanisms that characterize PD, and play a role in behavior change vs. persistence of behavior. Identifying these mechanisms is critical for testing and understanding treatments and uncovering who is most likely to respond to interventions.
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Inclusion and exclusion criteria
Inclusion Criteria (Problem Drinkers):
Inclusion Criteria (Healthy Controls):
Exclusion Criteria:
Primary purpose
Allocation
Interventional model
Masking
164 participants in 2 patient groups
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Central trial contact
Amy Mahony; Nasir Naqvi, MD, PhD
Data sourced from clinicaltrials.gov
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