Neural Circulatory Control and SUDEP Risk. (NC-SUDEP)
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About
The investigators believe epilepsy alters the way the body controls blood pressure, heart rate and breathing, and these changes increase the risk of sudden unexpected death in patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these changes to the heart and blood vessels. This research study measures those differences which may help identify new markers to help predict those patients at greatest risk in the future.
Full description
The investigators overall goals are to determine whether measures of neural-circulatory control during the interictal waking and sleep states, as well as during the ictal/peri-ictal periods, are associated with SUDEP-7 score risk profiles in refractory epilepsy patients, and to translate these measures into tools for risk-stratification and preventative strategies for SUDEP.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Adults aged 18-90
- Able to consent
Exclusion criteria
- History of non-epileptic spells/seizures,
- Children/adolescents under age 18 years
- Pregnancy
- Non-compliance with Epilepsy Monitoring Unit safety procedures
- Unable to consent
- History of dysautonomia
- Chronic Obstructive Pulmonary Disease (COPD)
- Asthma (active requiring therapy)
- Pulmonary hypertension
- Known Structural Heart Disease
- Heart failure
- Myocardial infarction
- Stroke
- Seizures due to traumatic injury
- Prior surgery for epilepsy
- Vasculitis
- Raynaud's
- Smoking (current or within the last 6 months)
Trial design
39 participants in 2 patient groups
Trial contacts and locations
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Central trial contact
Somers CPL Lab; Laura Hammel
Data sourced from clinicaltrials.gov
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