Neural Correlates of Compulsivity

Columbia University

Status: Completed

Conditions: Obsessive-Compulsive Disorder

Treatments: Behavioral: Exposure and Response Prevention (Ex/RP)

Study type: Observational

Funder types: Other

Identifiers

NCT05195476

7867

Details and patient eligibility

About

This study aims to collect data from individuals with obsessive-compulsive disorder (OCD) and healthy controls in order to clarify how learning strategies are employed differently by individuals with compulsive psychopathology and healthy individuals. Behavioral and electroencephalogram (EEG) data will be collected during one experimental reinforcement learning tasks from participants diagnosed with OCD (n = 30) and healthy controls (n = 30). Computational modeling, an advanced data analytic approach that can directly link neural measures with behavior, will be used to quantify learning processes. These parameters then will be related to measures of neural events obtained using EEG, a neuroimaging method that has high temporal resolution, to test for evidence of neurocognitive alterations.

Full description

Learning and decisions making are thought to be directed by multiple parallel cognitive systems. These systems account for automatic, inflexible responding to stimuli, as well as more deliberate, effortful representations of relationships in an environment. It has long been suggested than an imbalance in these cognitive control systems explains the emergence of compulsivity, a trait in which behaviors persist despite adverse outcomes. Compulsivity is a characteristic of a number of psychological disorders, however, current theories of how abnormalities in cognitive systems involved in learning and decision making lead to the onset of these disorders remain incomplete.

Enrollment: 41 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Between 18-50 years of age
• English-speaking
• Capacity to provide informed consent
• Primary diagnosis of OCD with at least moderate severity

Exclusion criteria

• Current or lifetime history of psychiatric disorders other than OCD that may increase the risk of participation
• History of any significant medical condition that may increase the risk of participation
• Alcohol or substance use disorder in the past year
• Exposure and response prevention for OCD within the last six weeks
• Currently taking psychotropic medication

Trial design

41 participants in 2 patient groups

Individuals diagnosed with OCD

Description:

Individuals diagnosed with OCD

Healthy controls

Description:

Individuals who have not been diagnosed with any psychiatric disorders