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Neural Correlates of Empathogenic and Affiliative Actions of Oxytocin (ODIS)

U

University Hospital Bonn (UKB)

Status and phase

Completed
Early Phase 1

Conditions

Healthy

Treatments

Drug: Oxytocin
Drug: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01701180
OXT-151/12 (Other Grant/Funding Number)

Details and patient eligibility

About

Mounting evidence indicates that the intranasal administration of the neuropeptide oxytocin has prosocial effects. However, the neural substrates of these effects are still unclear. The investigators hypothesized that a single dose administration of oxytocin should increase empathogenic and affiliative responses and that these effects are mediated by an increased insula activity.

Enrollment

23 patients

Sex

Male

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy male volunteers
  • In a heterosexual relationship

Exclusion criteria

  • Current or past psychiatric disease
  • Current or past physical illness
  • Psychoactive medication
  • Tobacco smokers

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Triple Blind

23 participants in 2 patient groups, including a placebo group

Oxytocin
Experimental group
Description:
24 IU Oxytocin, intranasal application 45 min prior to the experiment
Treatment:
Drug: Oxytocin
Placebo
Placebo Comparator group
Description:
Intranasal application, sodium chloride solution, 3 puffs per nostril
Treatment:
Drug: Placebo

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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