Neural Correlates of Self (NeuCoSe)

Civil Hospices of Lyon

Status: Completed

Conditions: Healthy Volunteers

Treatments: Behavioral: "control", "meditation", "hypnosis".

Study type: Interventional

Funder types: Other

Identifiers

NCT03206840

2017-A01923-50 (Other Identifier)

69HCL17_0274

Details and patient eligibility

About

Despite the increasing popularity of mindfulness meditation and hypnosis in healthcare and in the general community the underlying neurobiological mechanisms are unclear. The change in the relationship between the self and the conscious experience that they bring about may be crucial. This study aims to identify the neural correlates of self-consciousness in meta-awareness and absorption - using functional Magnetic Resonance Imaging (fMRI) in healthy participants combined with detailed first-person experiential accounts and behavioural tasks. This study will provide important clues about the widely reported effects of mindfulness meditation and hypnosis and shed light on the neural correlates of the conscious experience of self.

Enrollment: 100 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• aged 18-70
• Body mass index between 18.5 and 30
• Covered by health insurance
• motivated to participate
• signed informed consent
• normal or corrected-to-normal eyesight
• sufficient command of French to be able to follow the instructions

Exclusion criteria

• history of neurological or psychiatric conditions
• chronic pain or another medical condition altering pain perception
• use of medication that affects the central nervous system
• use of opioids or antidepressant medication
• severe auditory loss
• consumption of alcohol or intoxicants on the day of the experiments and the day preceding the experiments
• pregnancy, breastfeeding or having given birth <6months ago
• any contra-indication to Magnetic Resonance Imaging (metal implants or foreign bodies), agitation, claustrophobia

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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100 participants in 2 patient groups

Group 1

Experimental group

Description:

three instructions will be given to each participant: "control", "meditation", "hypnosis". The order of "meditation" and "hypnosis" will be randomized amongst two groups to avoid order effects.

Treatment:

Behavioral: "control", "meditation", "hypnosis".

Group 2

Experimental group

Description:

three instructions will be given to each participant: "control", "meditation", "hypnosis". The order of "meditation" and "hypnosis" will be randomized amongst two groups to avoid order effects.

Treatment:

Behavioral: "control", "meditation", "hypnosis".