Neural Mechanisms of Attention Lapses in Adult ADHD (AttLapse-TDA)

University Hospital, Strasbourg, France

Status

Completed

Conditions

Attention Deficit Disorder

Hyperactivity Disorder

Treatments

Other: Electroencephalography during sustained attention task.

Study type

Observational

Funder types

Other

Identifiers

NCT03948607

7248

Details and patient eligibility

About

ADHD is a common disorder, leading to a significant disability that often persists in adulthood. ADHD is characterized by attentional disturbances that are difficult to asses with standard neuropsychological tests.

Attention tends to stall after a certain time of fatigue (i.e. an attention lapse). The aim of this study is to study the electroencephalographic (EEG) characteristics of these attention lapses in a sustained attention task, comparing ADHD patients with healthy subjects.

Full description

The main goal is to assess with EEG the timing of the attentional demobilization that precedes a sustained attention lapse in patients with ADHD.

The secondary objectives are: 1 / To analyze impaired cognitive control mechanisms during lapses in patients with ADHD; 2 / Study the relationships between the deficits identified through EEG recording, clinical evaluations, and the subjective perception of daily difficulties; 3 / To measure the impact of the subjective attention state on the neuronal precursors of the attentional lapses; 4 / Evaluate the relation between propensity to wandering mind and attentional lapses.

Enrollment

63 patients

Sex

All

Ages

18 to 60 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Diagnosis of ADHD according to DSM-5 criteria by a psychiatrist with clinical experience with ADHD
aged 18 to 60
having signed an informed consent
able to understand the objectives and the risks related to the research

For Healthy controls

Absence of psychiatric disorder or neurological disease
Matched in sex, age (± 2 years) and level of study (± 2 years) to each ADHD patient

Exclusion criteria

treatment by Methylphenidate or amphetamine in the 3 months preceding the study
treatment by a psychotropic drug other than antidepressant SSRI: anti-depressant non-SSRI, antipsychotic, mood stabilizer, benzodiazepine or hypnotic daily intake
neurological pathology or neurological sequelae
history of head trauma with loss of consciousness of more than 15 minutes
Subject under the protection of justice
Subject under guardianship, curatorship
Subject in exclusion period (determined by previous or current study),
Impossibility to give the subject enlightened information (subject in emergency situation, difficulties of comprehension of the subject (for example mental retardation, illiteracy, subject not including French ...)