Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers

Technical University of Munich

Status and phase: Completed; Early Phase 1

Conditions: Drug Effects; Anesthesia

Treatments: Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02149927

56012/12

Details and patient eligibility

About

In imaging functional connectivity (FC) analyses of the resting brain, alterations of FC during unconsciousness have been reported. These results are in accordance to recent electroencephalographic studies observing impaired top-down processing during anesthesia. In this study, simultaneous records of functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG) were performed to investigate the causality of neural mechanisms during sevoflurane anesthesia by correlating FC in fMRI and directional connectivity (DC) in electroencephalogram.

Enrollment: 20 patients

Sex: Male

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ASA I
• male
• age > 18y

Exclusion criteria

• drug abuse
• history of psychiatric or neurologic diseases
• amblyacousia, deafness
• contradictions to the study drug (sevoflurane)
• implants
• piercings, tatoos

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Sevoflurane

Experimental group

Description:

Single arm: dose escalation of study medication

Treatment:

Drug: Sevoflurane