Neural Mechanisms Underlying Astigmatism

Sun Yat-sen University

Status: Unknown

Conditions: Astigmatism

Treatments: Behavioral: perceptual training

Study type: Interventional

Funder types: Other

Identifiers

NCT03735602

JYuan

Details and patient eligibility

About

This study is to compare the contrast sensitivity function and neural response to gratings before and after the orientation discrimination task in the astigmatism or amblyopia patients.

Full description

The presence of astigmatism can lead to substantial reductions in visual performance in a variety of clinical vision measures and functional visual tasks. However, the neural mechanisms underlying the astigmatism remains unknown. The current study recruited three groups (patients with with-the-rule astigmatism and amblyopia, patients with with-the-rule astigmatism but without amblyopia, normal controls) of subjects and patients receive perceptual learning training (orientation discrimination task) which lasts for around 15 days. This main aim is to compare the contrast sensitivity function and neural response to gratings before and after the orientation discrimination task in the astigmatism or amblyopia patients.

Patients with astigmatism or amblyopia were included in this study. All participants underwent an ophthalmic examination that included slit-lamp biomicroscopy, visual acuity, quick CSF under full optical correction, 9-SF life quality questionnaire and fundus examination.

Enrollment: 20 estimated patients

Sex: All

Ages: 10 to 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• high astigmatism

Exclusion criteria

• other types of disease (especially optical diseases) that may affect study

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

perceptual training

Experimental group

Description:

Orientation discrimination task, which is a cognitive task. Patients were trained for 1 hour per day, 15 days in total.

Treatment:

Behavioral: perceptual training