Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD) (NAVASYNC)

Hôpital Européen Marseille

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Device: NAVA; Other: Expiratory trigger (ET)

Study type: Interventional

Funder types: Other

Identifiers

NCT01042080

2009-A01099-48

Details and patient eligibility

About

NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway. The investigators hypothesized that NAVA improved patient-ventilator synchrony and reduced inspiratory workload as compared with pressure support ventilation delivered at two different cycling criteria (25 and 50 %).

Enrollment: 16 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of chronic obstructive pulmonary disease
• Admitted for acute respiratory failure requiring invasive mechanical ventilation
• Currently receiving pressure support ventilation

Exclusion criteria

• Age < 18 years
• Respiratory rate > 35 bpm
• Severe hypoxemia with SpO2 < 88 % and FIO2 > 50 %
• Heart rate > 120 bpm
• Systolic arterial pressure < 90 mmHg
• Contraindication to naso-gastric tube's insertion

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 3 patient groups

PSV-ET 25

Active Comparator group

Description:

Pressure support ventilation with expiratory trigger set at 25 %.

Treatment:

Other: Expiratory trigger (ET)

PSV-ET 50

Active Comparator group

Description:

Pressure support ventilation with expiratory cycling set at 50 %.

Treatment:

Other: Expiratory trigger (ET)

NAVA

Experimental group

Description:

NAVA level is adjusted to achieve similar peak inspiratory pressure levels than during PSV.

Treatment:

Device: NAVA