Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD) (NAVASYNC)

H

Hôpital Européen Marseille

Status

Completed

Conditions

Chronic Obstructive Pulmonary Disease

Treatments

Device: NAVA
Other: Expiratory trigger (ET)

Study type

Interventional

Funder types

Other

Identifiers

NCT01042080
2009-A01099-48

Details and patient eligibility

About

NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway. The investigators hypothesized that NAVA improved patient-ventilator synchrony and reduced inspiratory workload as compared with pressure support ventilation delivered at two different cycling criteria (25 and 50 %).

Enrollment

16 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • History of chronic obstructive pulmonary disease
  • Admitted for acute respiratory failure requiring invasive mechanical ventilation
  • Currently receiving pressure support ventilation

Exclusion criteria

  • Age < 18 years
  • Respiratory rate > 35 bpm
  • Severe hypoxemia with SpO2 < 88 % and FIO2 > 50 %
  • Heart rate > 120 bpm
  • Systolic arterial pressure < 90 mmHg
  • Contraindication to naso-gastric tube's insertion

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

16 participants in 3 patient groups

PSV-ET 25
Active Comparator group
Description:
Pressure support ventilation with expiratory trigger set at 25 %.
Treatment:
Other: Expiratory trigger (ET)
PSV-ET 50
Active Comparator group
Description:
Pressure support ventilation with expiratory cycling set at 50 %.
Treatment:
Other: Expiratory trigger (ET)
NAVA
Experimental group
Description:
NAVA level is adjusted to achieve similar peak inspiratory pressure levels than during PSV.
Treatment:
Device: NAVA

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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