Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction

University Hospitals (UH)

Status: Completed

Conditions: Non Invasive Ventilation; Patient Ventilator Interaction

Treatments: Device: Neurally Adjusted Ventilatory Assist

Study type: Interventional

Funder types: Other

Identifiers

NCT01074866

NAVA_NIV

Details and patient eligibility

About

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin.

Full description

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin. The subgroup of COPD patients will be analyzed separately. The effects of various setting of Neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Enrollment: 13 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients admitted to the ICU and treated with Non invasive ventilation for acute respiratory failure of any origin

Exclusion criteria

• severe hypoxemia requiring an FIO2>0.6
• hemodynamic instability
• known oesophageal problem
• active upper gastro-intestinal bleeding
• any other contraindication to the insertion of a naso-gastric tube
• impaired consciousness or absence of patient cooperation
• facial or laryngeal lesions contraindicating the use of NIV
• poor short term prognosis

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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13 participants in 2 patient groups

Pressure support

No Intervention group

Description:

Non invasive ventilation under pressure support (PS)

Neurally Adjusted Ventilatory Assist

Active Comparator group

Description:

Non invasive ventilation under Neurally Adjusted ventilatory Assist

Treatment:

Device: Neurally Adjusted Ventilatory Assist