Neuroaxial Prophylaxis for CABG

Volgograd State Medical University

Status and phase: Unknown; Early Phase 1

Conditions: Coronary Artery Occlusion

Treatments: Drug: thoracic epidural analgesia; Procedure: CABG; Drug: analgesia of opioids

Study type: Interventional

Funder types: Other

Identifiers

NCT04244435

TEA-CABG

Details and patient eligibility

About

Investigators plan to study the effect of thoracic epidural analgesia on postoperative parameters (complication rate, duration of hospitalization, mortality, etc.) of coronary artery bypass grafting.

Full description

Investigators plan to conduct a comparative analysis of early postoperative complications of coronary artery bypass grafting with and without cardiopulmonary bypass in patients with independent risk factors for the development of postoperative complications (advanced age, diabetes mellitus, chronic kidney disease, obesity, chronic obstructive pulmonary disease) with various types of anesthesiology benefits (general anesthesia and thoracic epidural analgesia versus general anesthesia and opioids). Investigators predict a decrease in the risk of developing cardiac, respiratory, infectious and renal complications, a reduction in the duration of intensive care, inpatient treatment and mortality.

Enrollment: 300 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• coronary artery bypass grafting

Exclusion criteria

• Absolute contraindications for the use of thoracic epidural analgesia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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300 participants in 3 patient groups

Thoracic epidural analgesia

Experimental group

Description:

CABG and thoracic epidural analgesia will be used for perioperative analgesia postoperative period

Treatment:

Drug: thoracic epidural analgesia

Procedure: CABG

Opioids

Active Comparator group

Description:

CABG and opioids will be used for perioperative analgesia

Treatment:

Drug: analgesia of opioids

Procedure: CABG

CABG

Active Comparator group

Description:

coronary artery bypass grafting with and without cardiopulmonary bypass

Treatment:

Procedure: CABG