Neurobehavioral Mechanisms of Cocaine Choice

Joshua A. Lile, Ph.D.

Status and phase: Completed; Early Phase 1

Conditions: Cocaine Use Disorder

Treatments: Behavioral: Money; Drug: Cocaine HCl

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04296006

R01DA045023 (U.S. NIH Grant/Contract)

BED(In)(41)

Details and patient eligibility

About

The objective of this protocol is to use a drug-vs-money choice task, reinforcement learning modeling and fMRI to determine the neurobehavioral and neurobiological decision-making "profile" associated with the decision to take cocaine and the reduced cocaine choice that occurs during a behavioral intervention (alternative money reinforcer) that models contingency management.

Enrollment: 15 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Recent cocaine use, otherwise healthy

Exclusion criteria

• Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

---

15 participants in 3 patient groups

$0.25 alternative reinforcer value

Experimental group

Description:

Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.

Treatment:

Drug: Cocaine HCl

Behavioral: Money

$1.00 alternative reinforcer value

Experimental group

Description:

Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.

Treatment:

Drug: Cocaine HCl

Behavioral: Money

$4.00 alternative reinforcer value

Experimental group

Description:

Subjects complete 200 trials on a probabilistic concurrent choice procedure in which 3 mg/70 kg intravenous cocaine and an alternative monetary reinforcer are available during each trial. Each money value is tested in a separate session.

Treatment:

Drug: Cocaine HCl

Behavioral: Money