Neurobehavioral Moderators of Post-traumatic Disease Trajectories

Tel Aviv Sourasky Medical Center

Status: Completed

Conditions: PTSD; Trauma

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03756545

0207-14-TLV

R01MH103287 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The research goal is to uncover the neurocognitive moderators of PTSD trajectories, by documenting clinical symptoms, cognitive functioning, and brain structure and function, one-, six- and fourteen months following a traumatic event, in a large population of survivors at initial high risk for PTSD.

Enrollment: 173 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 - 65 years
• Able to read and comprehend Hebrew
• Arrived in the ER because of one of the following: car accidents, terrorist attacks, work accidents, home accidents, burns, physical assault, large-scale disaster.

Exclusion criteria

• Individuals with known claustrophobia
• Individuals with history of substance abuse
• Individuals with current or past psychotic or bipolar I disorder
• Individuals with chronic PTSD at the time of the current trauma
• Individuals on psychotropic medication or recreational drugs in the week that precedes the MRI
• Individuals with hearing problems
• Individuals with head trauma with coma exceeding 30 minutes
• Individuals which can't perform MRI due to safety reasons (e.g. irremovable metals in their body)