Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model (SIGN)

University of Michigan

Status

Enrolling

Conditions

Healthy

Substance Use

Treatments

Behavioral: Behavioral tasks and eye tracking

Device: fMRI

Behavioral: Questionnaires and surveys

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT07094061

R01DA058010 (U.S. NIH Grant/Contract)

HUM00269332

Details and patient eligibility

About

This study seeks to understand individual differences in personality, brain function, and behavior.

Study hypothesis:

- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.

Enrollment

294 estimated patients

Sex

All

Ages

18 to 20 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

18-20 years old at baseline
Right-handed
Medically/physically able to give informed consent
English-speaking
Substance use is free to vary, but for participants with a history of substance use, ≥ 1 use of cannabis (including less than a full dose)

Exclusion criteria

Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
History of psychosis in self or first-degree relative
Current treatment for substance use disorder
Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
Intelligence quotient (IQ) < 70
Lifetime history of head trauma with loss of consciousness > 5 minutes
Reliance on glasses to be able to read small text at a distance of approximately 30 inches
Colorblindness
MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol