Neurobiological Aspects of the Attention Deficit Hyperactivity Disorder (NAADHD)

Federal University of Bahia

Status: Completed

Conditions: Attention Deficit Hyperactivity Disorder

Treatments: Device: Transcranial Direct Current Stimulation; Device: Sham

Study type: Interventional

Funder types: Other

Identifiers

NCT01968512

285.841

Details and patient eligibility

About

Evaluating neurobiological disorder associated with Attention Deficit Hyperactivity Disorder (ADHD) and the contribution of transcranial direct current stimulation (tDCS) in the adaptation of inhibitory control.

Full description

1. Assess the neurobiological aspects evidenced by the amount of brain electrical activity observed by the amplitude of waves through graphs in patients with ADHD, using quantitative electroencephalography;
2. Study the contribution of transcranial direct current stimulation compared with sham in the adequacy of inhibitory control in ADHD patients through neuropsychological test-Go/No Go;
3. Assessing the efficacy of tDCS in neurobiological parameters evidenced by quantitative EEG in patients with ADHD;
4. Perform the Reconstruction of the Functional Brain Network of each subject based on the quantitative EEG data through computational and mathematical modeling;
5. Register indicators of quality of life in adults with Attention Deficit Hyperactivity Disorder through the Quality of Life Questionnaire for Adults with ADHD (AAQoL).

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Signature of the informed consent;
• Diagnosis of Attention Deficit Hyperactivity Disorder based on DSM-IV-TR and Adult Self-Report Scale (ASRS-18);
• Adequate eyesight and hearing (or usual corrective methods such as glasses or hearing aid) that allows performing neuropsychological test and questionnaires;
• Residents in Bahia/Brazil;
• Over 18 years.

Exclusion criteria

• Major psychiatric disorders such as schizophrenia and bipolar disorder;
• Inability to understand the questionnaires used or illiterate;
• Abuse of psychoactive substances, except nicotine and caffeine, in the last 12 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Transcranial Direct Current Stimulation

Experimental group

Description:

Subjects will undergo to Transcranial Direct Current Stimulation with anode in left dorsolateral prefrontal cortex and cathode in right supra orbicular region. The stimulus will be 1mA for 20 minutes.

Treatment:

Device: Transcranial Direct Current Stimulation

TDCS-Sham

Sham Comparator group

Description:

Subjects will undergo to procedure similar to the Transcranial Direct Current Stimulation with anode in dorsolateral prefrontal cortex and left cathode region supraorbicular right. They will receive a stimulus of 1mA only in initial 30 seconds and it will change the electrical charge for 0mA after this time, however the electrodes will be kept for 20 minutes as the active arm.

Treatment:

Device: Sham